high throughput screening methods and protocols 3 edition methods in molecular biology book 1439

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High Throughput Screening

Author : William P. Janzen
ISBN : 9781592591800
Genre : Medical
File Size : 38. 60 MB
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Since its first use in antibiotic research in the 1940s, High Throughput Screening (HTS) has evolved into a major enabling tool and methodology in the discovery of pharmaceutical, chemical, and agricultural compounds. In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wished had been available when they started in HTS, these seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge. By presenting accounts not only of the basic principles underlying HTS technology, but also real-use cases, High Throughput Screening constitutes a highly practical introduction to HTS, even as it also provides sufficient detail to work more productively in today's lead generation laboratories.

Integrated Design For Space Transportation System

Author : B.N. Suresh
ISBN : 9788132225324
Genre : Technology & Engineering
File Size : 85. 87 MB
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The book addresses the overall integrated design aspects of a space transportation system involving several disciplines like propulsion, vehicle structures, aerodynamics, flight mechanics, navigation, guidance and control systems, stage auxiliary systems, thermal systems etc. and discusses the system approach for design, trade off analysis, system life cycle considerations, important aspects in mission management, the risk assessment, etc. There are several books authored to describe the design aspects of various areas, viz., propulsion, aerodynamics, structures, control, etc., but there is no book which presents space transportation system (STS) design in an integrated manner. This book attempts to fill this gap by addressing systems approach for STS design, highlighting the integrated design aspects, interactions between various subsystems and interdependencies. The main focus is towards the complex integrated design to arrive at an optimum, robust and cost effective space transportation system. The orbital mechanics of satellites including different coordinate frames, orbital perturbations and orbital transfers are explained. For launching the satellites to meet specific mission requirements, viz., payload/orbit, design considerations, giving step by step procedure are briefed. The selection methodology for launch vehicle configuration, its optimum staging and the factors which influence the vehicle performance are summarized. The influence of external, internal and dynamic operating environments experienced by the vehicle subsystems and the remedial measures needed are highlighted. The mission design strategies and their influence on the vehicle design process are elaborated. The various critical aspects of STS subsystems like flight mechanics, propulsion, structures and materials, thermal systems, stage auxiliary systems, navigation, guidance and control and the interdependencies and interactions between them are covered. The design guidelines, complexity of the flight environment and the reentry dynamics for the reentry missions are included. The book is not targeted as a design tool for any particular discipline or subsystem. Some of the design related equations or expressions are not attempted to derive from the first principle as this is beyond the scope of this book. However, the important analytical expressions, graphs and sketches which are essential to provide in-depth understanding for the design process as well as to understand the interactions between different subsystems are appropriately included.

Biochemistry And Molecular Biology Of Plants

Author : Bob B. Buchanan
ISBN : 9781118502211
Genre : Science
File Size : 65. 37 MB
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Biochemistry and Molecular Biology of Plants, 2nd Edition has been hailed as a major contribution to the plant sciences literature and critical acclaim has been matched by global sales success. Maintaining the scope and focus of the first edition, the second will provide a major update, include much new material and reorganise some chapters to further improve the presentation. This book is meticulously organised and richly illustrated, having over 1,000 full-colour illustrations and 500 photographs. It is divided into five parts covering: Compartments, Cell Reproduction, Energy Flow, Metabolic and Developmental Integration, and Plant Environment and Agriculture. Specific changes to this edition include: Completely revised with over half of the chapters having a major rewrite. Includes two new chapters on signal transduction and responses to pathogens. Restructuring of section on cell reproduction for improved presentation. Dedicated website to include all illustrative material. Biochemistry and Molecular Biology of Plants holds a unique place in the plant sciences literature as it provides the only comprehensive, authoritative, integrated single volume book in this essential field of study.

The Shock Of The Anthropocene

Author : Christophe Bonneuil
ISBN : 1784780790
File Size : 20. 62 MB
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Dissecting politically and historically the new theoretical buzzword of the Anthropocene

Molecular Biology Of The Cell Sixth Edition

Author : Bruce Alberts
ISBN : 9781317563754
Genre : Science
File Size : 75. 10 MB
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As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure_function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting –What We Donêt Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Natural Products Isolation

Author : Satyajit D. Sarker
ISBN : 9781592599554
Genre : Science
File Size : 51. 1 MB
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Natural Products Isolation: Second Edition presents a practical overview of just how natural products can be extracted, prepared, and isolated from the source material. Maintaining the main theme and philosophy of the first edition, this second edition incorporates all the new significant developments in this field of research. The chapters are divided into four distinct sections: introduction, extraction, chromatography, and special topics. This second edition provides substantial backround information for natural product researchers and will prove a useful reference guide to all of the available techniques.

The Science Of Flavonoids

Author : Erich Grotewold
ISBN : 9780387288222
Genre : Science
File Size : 83. 75 MB
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This is the only book of its kind to provide an overview of the science of flavonoids in plants.

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