computer simulation study of collective phenomena in dense suspensions of red blood cells under shear

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Computer Simulation Study Of Collective Phenomena In Dense Suspensions Of Red Blood Cells Under Shear

Author : Heinrich Krüger
ISBN : 9783834823755
Genre : Science
File Size : 77. 4 MB
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The rheology of dense red blood cell suspensions is investigated via computer simulations based on the lattice Boltzmann, the immersed boundary, and the finite element methods. The red blood cells are treated as extended and deformable particles immersed in the ambient fluid. In the first part of the work, the numerical model and strategies for stress evaluation are discussed. In the second part, the behavior of the suspensions in simple shear flow is studied for different volume fractions, particle deformabilities, and shear rates. Shear thinning behavior is recovered. The existence of a shear-induced transition from a tumbling to a tank-treading motion is demonstrated. The transition can be parameterized by a single quantity, namely the effective capillary number. It is the ratio of the suspension stress and the characteristic particle membrane stress. At the transition point, a strong increase in the orientational order of the red blood cells and a significant decrease of the particle diffusivity are observed. However, the average cell deformation shows no signature of the transition.

Mechanics Of The Cell

Author : David Boal
ISBN : 9780521113762
Genre : Science
File Size : 82. 36 MB
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New edition exploring the mechanical features of biological cells for advanced undergraduate and graduate students in physics and biomedical engineering.

Harpers Illustrated Biochemistry 29th Edition

Author : Robert Kincaid Murray
ISBN : 9780071765763
Genre : Medical
File Size : 81. 17 MB
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Gain a thorough understanding of the principles of biochemistry and molecular biology as they relate to modern medicine. Includes 16 case histories. Clear, concise, and in full color, Harper's This book unrivaled the ability to clarify the link between biochemistry and the molecular basis of disease. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's offers an organization and careful balance of detail and brevity not found in any other text on the subject. New to this edition: New chapters on Aging, Cancer, and Clinical Chemistry. Every chapter has been updated to reflect the latest advances in knowledge and technology. Each chapter now begins with a statement of objectives, followed by a brief discussion of the biomedical importance of topics discussed within the chapter. There are 250 multiple-choice questions to test your knowledge and comprehension. Increased number of tables that encapsulate important information, such as vitamin and mineral requirements.

Pharmaceutical Suspensions

Author : Alok K. Kulshreshtha
ISBN : 1441910875
Genre : Medical
File Size : 76. 11 MB
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The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.


Author : Nassim Nicholas Taleb
ISBN : 9780679645276
Genre : Business & Economics
File Size : 25. 41 MB
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Antifragile is a standalone book in Nassim Nicholas Taleb’s landmark Incerto series, an investigation of opacity, luck, uncertainty, probability, human error, risk, and decision-making in a world we don’t understand. The other books in the series are Fooled by Randomness, The Black Swan, and The Bed of Procrustes. Nassim Nicholas Taleb, the bestselling author of The Black Swan and one of the foremost thinkers of our time, reveals how to thrive in an uncertain world. Just as human bones get stronger when subjected to stress and tension, and rumors or riots intensify when someone tries to repress them, many things in life benefit from stress, disorder, volatility, and turmoil. What Taleb has identified and calls “antifragile” is that category of things that not only gain from chaos but need it in order to survive and flourish. In The Black Swan, Taleb showed us that highly improbable and unpredictable events underlie almost everything about our world. In Antifragile, Taleb stands uncertainty on its head, making it desirable, even necessary, and proposes that things be built in an antifragile manner. The antifragile is beyond the resilient or robust. The resilient resists shocks and stays the same; the antifragile gets better and better. Furthermore, the antifragile is immune to prediction errors and protected from adverse events. Why is the city-state better than the nation-state, why is debt bad for you, and why is what we call “efficient” not efficient at all? Why do government responses and social policies protect the strong and hurt the weak? Why should you write your resignation letter before even starting on the job? How did the sinking of the Titanic save lives? The book spans innovation by trial and error, life decisions, politics, urban planning, war, personal finance, economic systems, and medicine. And throughout, in addition to the street wisdom of Fat Tony of Brooklyn, the voices and recipes of ancient wisdom, from Roman, Greek, Semitic, and medieval sources, are loud and clear. Antifragile is a blueprint for living in a Black Swan world. Erudite, witty, and iconoclastic, Taleb’s message is revolutionary: The antifragile, and only the antifragile, will make it. Praise for Antifragile “Ambitious and thought-provoking . . . highly entertaining.”—The Economist “A bold book explaining how and why we should embrace uncertainty, randomness, and error . . . It may just change our lives.”—Newsweek “Revelatory . . . [Taleb] pulls the reader along with the logic of a Socrates.”—Chicago Tribune “Startling . . . richly crammed with insights, stories, fine phrases and intriguing asides . . . I will have to read it again. And again.”—Matt Ridley, The Wall Street Journal “Trenchant and persuasive . . . Taleb’s insatiable polymathic curiosity knows no bounds. . . . You finish the book feeling braver and uplifted.”—New Statesman “Antifragility isn’t just sound economic and political doctrine. It’s also the key to a good life.”—Fortune “At once thought-provoking and brilliant.”—Los Angeles Times From the Hardcover edition.

Lehninger Principles Of Biochemistry

Author : David Lee Nelson
ISBN : 1464109621
Genre : Biochemistry
File Size : 43. 34 MB
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"Clear writing and illustrations... Clear explanations of difficult concepts... Clear communication of the ways in biochemistry is currently understood and practiced. For over 35 years, in edition after bestselling edition, Principles of Biochemistry has put those defining principles into practice, guiding students through a coherent introduction to the essentials of biochemistry without overwhelming them. The new edition brings this remarkable text into a new era. Like its predecessors, Lehninger Principles of Biochemistry, Sixth Edition strikes a careful balance of current science and enduring concepts, incorporating a tremendous amount of new findings, but only those that help illustrate biochemistry's foundational principles. With this edition, students will encounter new information emerging from high throughput DNA sequencing, x-ray crystallography, and the manipulation of genes and gene expression, and other techniques. In addition, students will see how contemporary biochemistry has shifted away from exploring metabolic pathways in isolation to focusing on interactions among pathways. They will also get an updated understanding of the relevance of biochemistry to the study of human disease (especially diabetes) as well as the important role of evolutionary theory in biochemical research. These extensive content changes, as well as new art and powerful new learning technologies make this edition of Lehninger Principles of Biochemistry the most impressive yet." --Publisher description.

Encyclopedic Handbook Of Emulsion Technology

Author : Johan Sjoblom
ISBN : 1420029584
Genre : Science
File Size : 69. 1 MB
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A discussion of fundamental characteristics, theories and applications for liquid-liquid colloidal dispersions. It profiles experimental and traditional measurement techniques in a variety of emulsified systems, including rheology, nuclear magnetic resonance, dielectric spectroscopy, microcalorimetry, video enhanced microscopy, and conductivity.

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