biology of oral cancer key apoptotic regulators

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Biology Of Oral Cancer

Author : Prakash S. Bisen
ISBN : 9781466575622
Genre : Medical
File Size : 54. 57 MB
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Despite a decline in developed countries, cancer has consistently maintained its status as one of the top killers since time immemorial. Exploring cancer management and treatment at the molecular level, Biology of Oral Cancer: Key Apoptotic Regulators presents a key molecular event—apoptosis—in relation to genesis and progression of oral cancer. The book uses oral cancers as the specific means to demonstrate the use of apoptotic regulators for controlling cancers. The book comprehensively deals with the different aspects of oral cancer. The authors discuss strategies to leverage apoptotic regulatory mechanisms for better management along with state-of-the-art medical options available for management and treatment. Using an informal writing style that makes the information accessible to a wider audience, each chapter begins with a prologue followed by detailed discussion and concludes with a glimpse into future approaches and challenges. The book examines detection techniques that leverage molecular events associated with oral carcinogenesis to effectively detect oral cancer. A thorough examination of the internal (genetics) and external (carcinogens, radiation, and smoking) factors that cause cancer, the book provides an enhanced understanding of why oral cancer has consistently ranked among the top ten causes of cancer-related mortalities worldwide. It furthers the effective identification of the causal factors and their modulation that can restore cells’ normal state and be used to develop increasingly effective modalities.

Introduction To Cancer Biology

Author :
ISBN : 9788776814786
Genre :
File Size : 39. 57 MB
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"Introduction to Cancer Biology is a short primer on how cancers develop and grow. The aim of this book is to provide a gentle exploration of the fundamental concepts in a easy-to-understand format, using examples and key figures for illustration. It is written in a style to help the reader understand the six basic principles that inform our current understanding of cancer, at the molecular, cellular and physiological level. The text can be used either as a first step towards a deeper understanding of the mechanisms of cancer progression or it can be used as a quick revision guide. It would be suitable for anyone, with or without a background in biology."--Website.


Author : J. P. Mohr
ISBN : 9781437737806
Genre : Medical
File Size : 90. 19 MB
Format : PDF, ePub
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First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, Stroke: Pathophysiology, Diagnosis, and Management continues to provide the dependable, current answers you need to effectively combat the increasing incidence of this disease. Dr. J.P. Mohr, together with new associate editors Philip A. Wolf, James C. Grotta, Michael A. Moskowitz, Marc Mayberg, and Rüdiger von Kummer as well as a multitude of expert contributors from around the world, offer you updated and expanded coverage of mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more, equipping you to understand the latest scientific discoveries and make effective use of the newest approaches to diagnosis and treatment. Gain fresh perspectives and up-to-date insights from the world’s leading authorities on the pathophysiology, diagnosis, and management of stroke. Access the comprehensive, expert clinical guidance you need to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Make efficient and accurate diagnoses with the aid of abundant full-color CT images and pathology slides. Stay up to date on hot topics such as mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more.

Ccn Proteins

Author : Bernard Perbal
ISBN : 9781783260331
Genre : Science
File Size : 56. 53 MB
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The CCN Proteins are thought to play key roles in the biology of normal cell, tissue, organ, and body, and altered expression of CCN proteins is associated with several pathologies, including fibrosis and cancer. Because of its importance, the CCN field is expanding at a fast pace. Research articles in this field have recently increased logarithmically, and a book that is up-to-date, comprehensive, authoritative and affords insights into the biological roles of CCN proteins, is timely. CCN Protein: A New Family of Cell Growth and Differentiation Regulators presents the most recent progress in the field of CCN proteins, a new family of secretory signaling molecules that are involved in several fundamental biological progress. These proteins share a unique multimodular organization and present a partial identity with four families of regulatory proteins controling growth and development. The book covers the roles of CCN proteins in the control of cell proliferation and differentiation during normal development, wound repair, chondrogenesis and bone development, angiogenesis, tissue regeneration, fibrosis, renal diseases and cancer development. Contents: The CCN Family of Proteins: An Overview (B Perbal & M Takigawa)Roles of CCN2/CTGF in the Control of Growth and Regeneration (M Takigawa et al.)Integrin-Mediated CCN Functions (L F Lau & S C-T Lam)Expression and Roles of CCN2 During Odontogenesis (M Kanyama et al.)CCN Genes and the Kidney (B L Riser et al.)CCN Proteins in Liver Injury and Disease (A W Rachfal & D R Brigstock)Genetic Analysis of CCN Gene Function in Mammalian Development (L M Dornbach & K M Lyons)CCN Family in Embryonic Development (Non-Mammalian Models) (B Latinkic)CCN3 Expression and its Role During Development (K-I Katsube)Regulation of CCN Proteins by Alternations of the Cytoskeleton (B Chaqour & M Goppelt-Struebe)Pathogenesis of Systemic Sclerosis and CCN2 (Connective Tissue Growth Factor) (K Takehara)Function and Regulation of CCN5 (M R Gray & J J Castellot Jr)CCN3: A Multifunctional Signaling Regulator (N Planque et al.)CCN Proteins and Connexins: Interactions and Growth Control (C Fu et al.)The Role of CCN1 in Tumorigenesis and Cancer Progression (J O'Kelly & H P Koeffler)CCN4 and CCN6 Variants in Wnt-Inducible Signaling Pathway (S Tanaka) Readership: Biochemists, biologists, molecular biologists, physiologists, pathologists, and medical and dental doctors interested in the study of CCN proteins, growth factors, extracellular matrix proteins, signaling molecules, and mechanisms of gene expression. Key Features:First such book in the CCN fieldChapters are written by the most prominent specialists in the fieldKeywords:Cyr 61;CTGF;NOV;WISP;Elm-1;rCop-1;Growth Factor;Extracellular Matrix;Signaling;Gene Expression;Cancer Fibrogenesis

Cancer Of The Skin

Author : Eggert Stockfleth
ISBN : 9781437736144
Genre : Medical
File Size : 63. 73 MB
Format : PDF, Kindle
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Cancer of the Skin, edited by Drs. Rigel, Robinson, Ross, Friedman, Cockerell, Lim, Stockfleth, and Kirkwood, is your complete, multimedia guide to early diagnosis and effective medical and surgical treatment of melanoma and other skin cancers. Thoroughly updated with 11 new chapters, this broad-based, comprehensive reference provides you with the latest information on clinical genetics and genomics of skin cancer, targeted therapy for melanoma, the Vitamin D debate concerning the risks and benefits of sun exposure, and other timely topics. A new, multi-disciplinary team of contributors and editors comprised of leading experts in this field offers truly diverse perspectives and worldwide best practices. Broaden your understanding of all aspects of skin cancer—from the underlying biology to clinical manifestations of the disease to diagnosis, and medical and surgical treatment—with this easy-to-use, comprehensive, multimedia reference. See conditions as they appear in practice with guidance from detailed full-color images and step-by-step procedural videos. Stay current with the latest advancements and therapies! 11 new chapters cover clinical genetics and genomics of skin cancer, targeted therapy for melanoma, the Vitamin D debate concerning the risks and benefits of sun exposure, and other essential topics. Get truly diverse perspectives and worldwide best practices from a new, multi-disciplinary team of contributors and editors comprised of the world’s leading experts Access the complete text online—including image bank and video library—at

Molecular Biology Of The Cell

Author : Bruce Alberts
ISBN : 0824036956
Genre : Science
File Size : 60. 84 MB
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New edition of a text in which six researchers from leading institutions discuss what is known and what is yet to be understood in the field of cell biology. The material on molecular genetics has been revised and expanded so that it can be used as a stand-alone text. A new chapter covers pathogens, infection, and innate immunity. Topics include introduction to the cell, basic genetic mechanisms, methods, internal organization of the cell, and cells in their social context. The book contains color illustrations and charts; and the included CD-ROM contains dozens of video clips, animations, molecular structures, and high-resolution micrographs. Annotation copyrighted by Book News Inc., Portland, OR.

Cancer New Insights For The Healthcare Professional 2011 Edition

Author :
ISBN : 9781464900020
Genre : Medical
File Size : 50. 45 MB
Format : PDF, Docs
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Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

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